Thomson's shortlist for 2011 (here) now includes Fritz Vögtle, Donald Tomalia and Jean Fréchet for their work on dendrimers which may problematic as there are other pioneers in this field alive and well. One other name in this list Allen J. Bard is equally problematic because as far as the Wikipedia community is concerned his contribution to science - scanning electrochemical microscopy - is irrelevant. Sure, there is a biopage but no page on this type of microscopy or even a single Bard citation on any page.
Predictions aside, it will be equally interesting to see how the media will eventually handle the winning science. Science journalists must occasionally be lost for words. How to sell the prize to the general public! In 2005 when the prize was in the field of olefin metathesis it was described as an innovative way to reduce chemical waste by the leading TV news bulletin in the Netherlands which may be true but is beside the point. Last year when the prize was all about coupling reactions the same bulletin skipped to item all together.