It is Nobel time again (October 6) and for the Nobel Prize in Chemistry 2010 prediction we can just rerun the contestants from 2008 and 2009, check their health and scrap the ones who have already won (although there is no law preventing someone winning twice).
Summing up in terms of clusters the potential winners are Barton/Giese/schuster (DNA electron transfer), Lieber/Whitesides/Stoddard (nanotech advance) and Karplus/Bax (biomolecular structure elucidation). More 2010 predictions in the bloggosphere: by chembark and by Everyday Scientist.