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The Bargellini reaction

The Bargellini reaction
02 May 2009 - Named reactions

Name: Bargellini reaction - Bargellini, G. Gazz. Chim. Ital. 1906, 36, 329
What: multicomponent reaction of a phenol, a ketone, chloroform and potassium hydroxide forming a sterically hindered alpha-phenoxy-isobutyric acid:

Recent sightings: the reagent chloretone is the ketone and chloroform rolled in one for example (Cvetovich et al. DOI):

The reaction is also found to work with aniline derivatives (Butcher et al. DOI):