|Quick update on platensimycin total synthesis with two stragglers (see earlier post here). Matsuo et al. (DOI) create the tetracyclic core in a radical reaction akin the Barton-McCombie deoxygenation:|
The synthesis of the precursor molecule is a thiol ene reaction with thiophenol.
Ghosh & Xi (DOI) obtain a similar looking derivative through an intramolecular Diels-Alder reaction: