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Platensimycin update
31 January 2009 - Total synthesis
Quick update on
platensimycin
total synthesis
with two stragglers (see earlier post
here
). Matsuo et al. (
DOI
) create the tetracyclic core in a radical reaction akin the
Barton-McCombie deoxygenation
:
The synthesis of the precursor molecule is a
thiol ene reaction
with
thiophenol
.
Ghosh & Xi (
DOI
) obtain a similar looking derivative through an intramolecular
Diels-Alder reaction
:
NNNS chemistry blog 
