Pd catalysed ketones from alkenes

13 March 2013 - CRD 114

Publication : Morandi / Wickens / Grubbs DOI
Substrate : internal alkene
Product: ketone
Active catalyst: Pd(MeCN)4(BF4)2
Oxidizing agent: Benzoquinone, can be replaced by oxygen balloon
Observations: DMA cosolvent suppresses isomerization, in 4-octene the cis isomer reacts faster.
Ketone synthesis Grubbs 2013.PNG