NNNS chemistry blog http://chem.vander-lingen.nl Chemistry blog : news - comments - basics in chemistry en-us 1440 Asymmetric alpha C-H activation http://chem.vander-lingen.nl/articles/Asymmetric alpha C-H activation/id/254/itemid/862 A recent contribution from the Guosheng Liu laboratory concerns the asymmtric version of a copper catalysed alpha C-H-activation (Wen Zhang , Fei Wang DOI). This work builds on the classic Kharasch-Sosnovsky reaction. The substrates are benzylic compounds with unactivated protons at the alpha po Saturday 24 Sep 2016 21:23:37 Asymmetric beta C-H activation http://chem.vander-lingen.nl/articles/Asymmetric beta C-H activation/id/254/itemid/861 A recent contribution from the Kendall Houk laboratory concerns the asymmtric version of a palladium catalysed beta C-H-activation (Gang Chen et al. DOI). This work builds on work done by Giri et al. in 2005 on asymmetric Pd iodination (DOI). The substrates are amides with unactivated protons a Saturday 24 Sep 2016 13:24:11 Hoffmann on citations http://chem.vander-lingen.nl/articles/Hoffmann on citations/id/254/itemid/860 Hoffmann, Kabanov, Golov, and Proserpio have a thing to say about citations in a recent 15 page Angewandte essay (DOI) 1). The bottom line: do not be lazy citing work and with modern search capabilities there is no excuse really to not being able to find previous work. Here are some entertaining q Thursday 22 Sep 2016 19:25:14 Green pool mystery solved http://chem.vander-lingen.nl/articles/Green pool mystery solved/id/253/itemid/859 The Olympic green swimming pool mystery has been solved. See media coverage from The Independent and Buzzfeed For days one of the pools was changing into an ever darker color of green in sharp contrast to the pool next to it. Swimmers had good reason to fear for their health. The green was of a dis Sunday 14 Aug 2016 15:27:53 The galinstan swimmers http://chem.vander-lingen.nl/articles/The galinstan swimmers/id/253/itemid/858 Making-it-move research ordinarily is a pretty obscure branch of chemical physics but this week one exploit caught the attention of mainstream newspaper The Independent here. Something to do with a likeness to a science-fiction fantasy. As reported by Zavabeti et al. in Nature Communications (DOI - Saturday 06 Aug 2016 16:34:27 Leidenfrost chemistry http://chem.vander-lingen.nl/articles/Leidenfrost chemistry/id/252/itemid/857 A nice proof of concept here at The Angewandte exploiting the Leidenfrost effect in a chemical reaction. Ryan Bain et al. have asked themselves the question: can a reaction accelerate when confined to a tiny droplet levitating on a hot surface? The experimental setup was a simple petri dish on top Thursday 28 Jul 2016 21:31:36 Oseltamivir 61 http://chem.vander-lingen.nl/articles/Oseltamivir 61/id/252/itemid/856 Is this really oseltamivir total synthesis number 61? We stopped counting the last time at number 27. Soon there will be a Journal of Oseltamivir Synthesis. Hayashi and Ogasawara present effort no 61 in Organic Letters (DOI) and Time Is Money! The opening paragraph contains two non-truths: "It is Friday 08 Jul 2016 21:51:02 BP super fuel launch http://chem.vander-lingen.nl/articles/BP super fuel launch/id/251/itemid/855 Today, at the counter of my gas station I was greeted by a BP leaflet. The topic was "ACTIVE technology" with "BP Ultimate", advertised as "our best formula for eliminating dirt in your engine", all in Dutch off course. The leaflet went on: standard fuels can lead to dirt accumulating in the car en Friday 01 Jul 2016 19:34:10 Rock-solid carbon dioxide http://chem.vander-lingen.nl/articles/Rock-solid carbon dioxide/id/251/itemid/854 Uncertain how the climate-alarmists will get around this one - 'upsets the basalt ecosystem' - 'we need more science!' but the Icelanders seem to have solved the carbon dioxide sequestration problem according to this paper by Matter et al. in the journal Science. The big issue with sequestration dee Friday 10 Jun 2016 23:10:22 Target ophiobolin http://chem.vander-lingen.nl/articles/Target ophiobolin/id/250/itemid/853 In a week with new alarming antibiotic-resistent superbug news (here) it is nice to know that least some people make the effort to make new antibacterial drugs. The synthetic target this week is a sesterterpene of the ophiobolin family and its creators Brill, Grover and Maimone of the University of Saturday 28 May 2016 14:15:37 Fun with ContentMine http://chem.vander-lingen.nl/articles/Fun with ContentMine/id/250/itemid/852 With 206 chemical reactions amassed in 4 years the CRD (Chemical Reaction Database) is not really making progress. For earlier episodes see here, here, here, here, here, here, here, here, here, here, here, here, here, here, here,here and here. What is clearly lacking is the motivation to enter the d Friday 06 May 2016 00:04:46 Novel photochemical ammonia synthesis http://chem.vander-lingen.nl/articles/Novel photochemical ammonia synthesis/id/249/itemid/851 In nature, bacteria convert nitrogen to ammonia using a iron-molybdenum cofactor (FeMoCo) and a lot of ATP. As ammonia is valuable, chemists have been working on a synthetic ammonia synthesis process for ages that thus far has only yielded the brute-force high-temperature high pressure Haber process Friday 22 Apr 2016 23:51:04 2D-boron http://chem.vander-lingen.nl/articles/2D-boron/id/249/itemid/850 If you want to read up on the new two-dimensional boron sheets unrolled by Baojie Feng et al. you have options: choose either 'Experimental Realization of Two-Dimensional Boron Sheets' as published on arxiv (link, free-access) submitted 16 december 2015 or choose "Experimental realization of two-dim Friday 08 Apr 2016 21:10:19 Gas-phase SN2 rethink http://chem.vander-lingen.nl/articles/Gas-phase SN2 rethink/id/249/itemid/849 Interesting perspective by Xie and Hase in this week's Science on the topic of bimolecular nucleophilic substitution (SN2), The title "Rethinking the SN2 reaction" sounds alarming but only the gas-phase variety is in need of a reconsideration. So what is going on: the textbooks all present SN2 (X` Saturday 02 Apr 2016 14:56:18 Double methane borylation http://chem.vander-lingen.nl/articles/Double methane borylation/id/248/itemid/848 Interesting double paper header in this week's issue of the journal science, a methane borylation and a methane borylation! A University of Michigan team beat a University of Pennsylvania team by just 6 days! And as coincidences do not exist in chemical land this is worth investigating. Team Michig Sunday 27 Mar 2016 20:24:08 Energy storage on a large scale http://chem.vander-lingen.nl/articles/Energy storage on a large scale/id/248/itemid/847 Energy company Nuon announced today it will convert one of its gas power plants in The Netherlands into a ammonia / energy storage facility. The first in the world of this type (Link). This facility that goes by the name 'Magnum' opened in 2013 as a multi-fuel plant capable of processing gas, coal a Saturday 26 Mar 2016 15:39:15 Things to do with http://chem.vander-lingen.nl/articles/Things to do with /id/248/itemid/846 Things to do with a fullerene. Things to do with water and a fullerene. Things to do with water inside a fullerene? Things to do with two water molecules inside a C70 fullerene! This must have been the sort of thinking that went on inside the head of Yasujiro Murata. 15 years ago he brought you endo Monday 29 Feb 2016 22:11:36 Novel transfer hydrocyanation http://chem.vander-lingen.nl/articles/Novel transfer hydrocyanation/id/247/itemid/845 News in organic hydrocyanation. Reliance on hydrogen cyanide for any alkene hydrocyanation is taken for granted. Major disadvantages though: the gas is a poison for humans, the gas also tends to poison the catalyst. In a recent Science article Fang, Yu and Morandi describe an alternative approach Wednesday 10 Feb 2016 21:40:36 Sci Hub pirates http://chem.vander-lingen.nl/articles/Sci Hub pirates/id/247/itemid/844 With thanks to Rich Apodaca for the Twitter alert. A pirate-bay for science enthusiasts has been around for some time called Sci-Hub and without me knowing about it. Has Christmas arrived early this year? Or should this blog behave responsibly and condemn it? It is not like I lack access to the chem Tuesday 19 Jan 2016 22:24:28 Yttrium ferricyanide http://chem.vander-lingen.nl/articles/Yttrium ferricyanide/id/246/itemid/843 In the chemical zoo this week: yttrium ferricyanide YFe(CN)6. Otherwise a truly unremarkable compound but for one property: its compressibility. Duyker et al. report about it in Nature Chemistry (DOI). Measuring it is one thing: 25% at 1.5 Gpa - by neutron powder diffraction - but figuring out how e Sunday 17 Jan 2016 21:55:25