NNNS chemistry blog http://chem.vander-lingen.nl Chemistry blog : news - comments - basics in chemistry en-us 1440 Olefin hydroamination latest http://chem.vander-lingen.nl/articles/Olefin hydroamination latest/id/238/itemid/816 Latest from the Baran laboratory: Olefin hydroamination. (Gui et al. DOI) Key ingredients: an alkene and a nitro arene together with triphenylsilane (2 eq.), ferric acetylacetonate (30 mole%), zinc, HCl and ethanol. The product: the alkylated amine. Product optimisation and substrate scope are all Friday 22 May 2015 22:42:18 Walk like an inchworm http://chem.vander-lingen.nl/articles/Walk like an inchworm/id/238/itemid/815 In a new episode of Making-It-Move (previous one here) molecular walkers take the stage as reported by Haq et al. (DOI) . Walking or self-driving molecules have been around for some time. Unidirectional motion has not yet been achieved (the molecules stagger back and forth) and the new walker is not Saturday 16 May 2015 13:16:17 Get more out star anise http://chem.vander-lingen.nl/articles/Get more out star anise/id/238/itemid/814 The compound shikimic acid is a natural precursor in the production of the synthetic (and supposedly) anti-influenza drug oseltamivir (Tamiflu). See Oseltamivir total synthesis and previous blog episodes here, here, here, here and here. Nice to know that researchers from the School of Physical Scien Wednesday 13 May 2015 18:50:06 Safe acetylene source http://chem.vander-lingen.nl/articles/Safe acetylene source/id/238/itemid/813 Matake, Niwa, and Matsubara report a new way to generate acetylene for research laboratory use. (DOI) The method is based on a phase-vanishing reaction (PV method): in a test tube a layer of fluorous solvent separates two reactive media that exchange reactants by slow diffusion, the reaction product Saturday 09 May 2015 17:21:22 Disilicon tetroxide http://chem.vander-lingen.nl/articles/Disilicon tetroxide/id/237/itemid/812 Disilicon tetroxide (Si2O4) is not supposed to exist just like the carbon analogue 1,3-dioxetanedione. But why not give it a try. The research group of Gregory Robinson reporting the synthesis of a stabilised silicon oxide (DOI) has had already discovered carbene-stabilized disilicon L:Si=Si:L with Thursday 23 Apr 2015 22:58:33 ZrIrSb http://chem.vander-lingen.nl/articles/ZrIrSb/id/237/itemid/811 You would expect that by now chemists haver tackled all small molecules and have ventured on with the larger ones. This is far from the truth. Simple binary compounds continue to pose problems and large tracts of the small ternary compound landscape are still unknown to science. It is therefore a ha Saturday 04 Apr 2015 12:36:10 OPRD solvent survey http://chem.vander-lingen.nl/articles/OPRD solvent survey/id/236/itemid/810 A group of researchers from Pfizer and GlaxoSmithKline have been datamining the journal Organic Process Research and Development for solvents and report about it here. The chemistry detailed in this journal may be typical of what is happening in chemistry industry with procedures in the 1 to 100 K Saturday 28 Mar 2015 19:05:26 Limitless power by water droplets http://chem.vander-lingen.nl/articles/Limitless power by water droplets/id/236/itemid/809 In the latest of fantastic endless renewable energy schemes: energy harvested from falling raindrops on a surface (think roof tile and gutter) as devised by Yajuan Sun, Xu Huang and Siowling Soh (DOI) from the National University of Singapore (annual precipitation: 2,340 mm). The basics: water drop Friday 27 Mar 2015 18:46:46 On Frank Weinhold http://chem.vander-lingen.nl/articles/On Frank Weinhold/id/236/itemid/808 Frank Weinhold is Professor Emeritus at the University of Wisconsin. A chemist with a talent for attracting controversy so it seems. He recently found himself in hot scientific debate on two occasions. Last year together with Roger Klein, Weinhold introduced the concept of the "anti-electrostatic hy Saturday 14 Mar 2015 21:53:15 Meet Derk Haank http://chem.vander-lingen.nl/articles/Meet Derk Haank/id/235/itemid/807 Meet Derk Haank. He used to run Elsevier Science, now runs Springer. Haank is a pretty important figure in scientific publishing. Springer recently acquired MacMillan. Mac Who? That is the German Von Holtzbrinck family and proud owners of the journal Nature. Who is better positioned to present a cou Friday 27 Feb 2015 21:10:07 Fluorenyl cation trapped http://chem.vander-lingen.nl/articles/Fluorenyl cation trapped/id/235/itemid/806 Fluorene is a typical aromatic compound and so is it's anion. The fluorenyl cation on the other hand is antiaromatic and any attempt to synthesising it would seem a futile exercise. Where some of the giants in chemistry like Olah and Schleyer tried anyway and failed some 30 years ago actual synthesi Saturday 21 Feb 2015 21:33:22 Terpenes-in-a-box http://chem.vander-lingen.nl/articles/Terpenes-in-a-box/id/235/itemid/805 In an example of lab imitating nature tail-to-head terpene cyclization is found to take inside the cavity of a certain resorcinarene mimicking an enzyme (Zhang and Tiefenbacher DOI). The resorcinarene capsule is hydrophobic with a cavity of 1.4 A. The walls are aromatic allowing favourable cation- Saturday 21 Feb 2015 18:38:55 Reaction in hot water http://chem.vander-lingen.nl/articles/Reaction in hot water/id/234/itemid/804 The latest reaction inducted in the Chemical Reaction Database (CRD) is lifted from an article by Feng-Zhi Zhang et al. (DOI) about intramolecular etherification by activated alcohols. Is hot water as advertised in the title an efficient reaction promotor? Or is water just a terrible solvent given t Friday 16 Jan 2015 21:24:51 The War on Elsevier http://chem.vander-lingen.nl/articles/The War on Elsevier/id/234/itemid/803 The Dutch universities are at war with scientific publisher Elsevier. The newspaper NRC with Marcel aan de Brugh has the story. The universities are demanding that Elsevier adopts an affordable open access business model. If it is up to Gerard Meijer, the chief university negotiator, a boycott will Tuesday 13 Jan 2015 20:29:47 The state of Bachelor level education http://chem.vander-lingen.nl/articles/The state of Bachelor level education/id/234/itemid/802 You may have missed it: an ambitious survey on the so-called skills gap in Bachelor level education as published in the Journal of Chemical Education (DOI). What do chemical companies think of Bachelor level education? There is some interesting data to be found. For example for organic chemists in c Saturday 10 Jan 2015 13:06:03 Phosphinoboration http://chem.vander-lingen.nl/articles/Phosphinoboration/id/234/itemid/801 In a recent report (DOI) Daley et al. express surprise that of the many bonds containing boron that have been used in the exploration of addition reactions, for example the B-H bond in hydroboration, the boron - phosphorous bond is not one of them. Triggered by a 2013 report by Breuning (DOI), the f Sunday 04 Jan 2015 16:07:29 Elsewhere on the internet http://chem.vander-lingen.nl/articles/Elsewhere on the internet/id/233/itemid/800 This blog (if you can call it one) conspicuously does not have a blogroll. Practical reason one: the content management system this blog is written on was conceived before blogs became mainstream and the developer is particularly lazy. Practical reason two: a blogroll is one thing but you only want Wednesday 31 Dec 2014 13:24:06 Another asbestos scare http://chem.vander-lingen.nl/articles/Another asbestos scare/id/233/itemid/799 In 2012 authorities in the the Dutch town of Utrecht cordoned off an entire city street on account of asbestos contamination (Link). If you think that was over the top, the city of Roermond (population 57,000 and also in The Netherlands) did one better this week, they closed the entire city centre. Saturday 20 Dec 2014 12:26:09 A giant wheel http://chem.vander-lingen.nl/articles/A giant wheel/id/233/itemid/798 May, Jester and Höger report on a new giant of a molecule IN JACS (DOI). This blog has been taken an interest in chemical giants before. Here are the characteristics: it is a C<sub>1878</sub>H<sub>2682</sub> hydrocarbon resembling a spoked hexagonal wheel. The spokes and rim consist of phenylene-et Tuesday 02 Dec 2014 19:02:14 New in asymmetric photochemistry http://chem.vander-lingen.nl/articles/New in asymmetric photochemistry/id/232/itemid/797 Rijeesh et al. report a novel photoinduced enantioselective reaction DOI It has been done before: in 1971 Kagan directed circularly polarized light (CLP) at a complex hydrocarbon forming a chiral helicene. The CLP handedness matched that of the helicene handedness. In the novel reaction the subs Tuesday 18 Nov 2014 21:30:13