NNNS chemistry blog http://chem.vander-lingen.nl Chemistry blog : news - comments - basics in chemistry en-us 1440 MicroED for Joe Molecule http://chem.vander-lingen.nl/articles/MicroED for Joe Molecule/id/280/itemid/913 Was getting a lot of mentions on Twitter this week: MicroED for small ordinary molecules by Brian Stoltz and Tamir Gonen. (DOI) Organic chemists are excited because of the promise of a new easy-to-exploit tool for molecular structure elucidation. Transmission electron cryomicroscopy (cryoTEM Thursday 18 Oct 2018 22:14:43 Optical tweezers for chemists http://chem.vander-lingen.nl/articles/Optical tweezers for chemists/id/280/itemid/912 Part of the 2018 Nobel Prize in Physics was awarded to Arthur Ashkin for his invention of optical tweezers in 1986. If you want to know what these are look no further than Youtube University for example with Styropyro demonstrating levitating nano-diamonds in a laser (link) or Phils Musical Snippets Saturday 13 Oct 2018 21:04:38 Free garlic recipe http://chem.vander-lingen.nl/articles/Free garlic recipe/id/279/itemid/911 Looking for a new garlic recipe? Move on to another blog. This one is on Filipa Silva et al. as published in the Angewandte. It requires a chemical lab and not a kitchen. Biomolecule ajoune is one of the compounds that make garlic garlic. It has been demonstrated before it can be made synthetically Friday 14 Sep 2018 22:53:22 Calcium octacarbonyl http://chem.vander-lingen.nl/articles/Calcium octacarbonyl/id/279/itemid/910 In the chemical zoo this month: calcium octacarbonyl as reported by Xuan Wu et al. in the journal science. (link) The habitat of this creature is very limited and confined to a laboratory in Shanghai and then even only at 4 degrees above the absolute freezing point and guarded by neon. metal carb Tuesday 04 Sep 2018 22:25:35 The Netherlands and illegal drugs http://chem.vander-lingen.nl/articles/The Netherlands and illegal drugs/id/278/itemid/909 Nothing to be proud of from the pages of a new report "The Netherlands and synthetic drugs: an inconvenient truth" published by the Dutch National Police Academy (pdf here) The Dutch are global leaders in the manufacture of illegal synthetic drugs (XTC and amphetamines) with an conservative estimate Sunday 26 Aug 2018 10:53:34 A cloud of soil http://chem.vander-lingen.nl/articles/A cloud of soil/id/277/itemid/908 The Americans may have Silicon Valley but the Dutch have the Food Valley, a conglomerate of food companies and Wageningen University. A recent innovation from this region as reported by NOS News (Link) is a handheld scanner for the determination of soil quality by company SoilCares. The scanner, he Friday 06 Jul 2018 22:13:28 Europe running out of carbon dioxide http://chem.vander-lingen.nl/articles/Europe running out of carbon dioxide/id/276/itemid/907 The journal Gasworld has a scoop: Europe is running out of carbon dioxide gas (link) affecting the availability of carbonated drinks among other things. The production of carbon dioxide for human use is curiously linked to that of ammonia, the Haber-Bosch process requires hydrogen gas which is produ Tuesday 26 Jun 2018 21:57:34 Curiosity does it again http://chem.vander-lingen.nl/articles/Curiosity does it again/id/276/itemid/906 I have the Curiosity rover in my Twitter contacts and last Thursday it had some great news to share, organic material found at last! The research done it had its colleagues on Earth write it all up in an article in Science. (DOI). Here are the key findings. The soil drill site was on a mudstone sur Friday 08 Jun 2018 21:48:48 DIY Vorinostat http://chem.vander-lingen.nl/articles/DIY Vorinostat/id/275/itemid/905 It does not stop: after Orkambi (link) and chenodeoxycholic acid (link) we now have another enterprising Dutch dispensing pharmacist home-brewing a an otherwise really expensive drug (NOS news). This time the drug is Vorinostat now available for patients at the AVL hospital not for the retail price Thursday 10 May 2018 21:14:45 Whitesides on total synthesis http://chem.vander-lingen.nl/articles/Whitesides on total synthesis/id/274/itemid/904 George Whitesides has recently shared his thoughts on organic synthesis in an essay in The Israel Journal of Chemistry (DOI) In it he asks the big question about its future. Being a functional materials man Whitesides of course contrasts the aesthetics of complex biomolecule synthesis with the pract Saturday 14 Apr 2018 10:37:32 Baran on Total Synthesis http://chem.vander-lingen.nl/articles/Baran on Total Synthesis/id/274/itemid/903 Almost written as a counter-essay to the Whitesides article on Organic Synthesis, Phil Baran has expressed his take on total synthesis in a recent JACS editorial. (DOI). The title suggests it is just another propaganda piece: "As Exciting as Ever and Here To Stay" but you cannot blame him. According Saturday 07 Apr 2018 17:55:03 DIY chenodeoxycholic acid http://chem.vander-lingen.nl/articles/DIY chenodeoxycholic acid/id/274/itemid/902 In a previous episode this blog has been reporting on a Dutch dispensing chemist who took it on himself the affordable production of a certain drug, otherwise only available from the pharmaceutical industry at highly inflated prices. This week in the news (link) a hospital doing something similar. Friday 06 Apr 2018 18:23:47 New in phosphorus chemistry http://chem.vander-lingen.nl/articles/New in phosphorus chemistry/id/273/itemid/901 How to recap this article: how to get from phosphate rock to drug fosinopril, but in two different ways? Seems a bit odd, just like discussing the merits of oil production from in the context of aspirin synthesis. <br /><br /> Geeson and Cummins do just that in a recent Science article (DOI). They Friday 30 Mar 2018 20:42:49 The physics of ice scating http://chem.vander-lingen.nl/articles/The physics of ice scating/id/272/itemid/900 With the start of the 2018 Winter Olympics it seemed my local newspaper The Volkskrant a great idea to include a segment on one of the great unsolved problems in physics: ice scating. If you look at the current unsolved problems Wikipedia page the official list contains the heavy-weight issues from Saturday 10 Feb 2018 22:03:37 Energy crisis in The Netherlands http://chem.vander-lingen.nl/articles/Energy crisis in The Netherlands/id/272/itemid/899 The Gasmolecule is a sculpture of a methane molecule with a height of 8 meters and is located in Slochteren in the province of Groningen in the North of the Netherlands. The sculpture commemorates the find of a massive natural gas field (2700 billion cubic meters) in 1959 that has since provided mil Friday 02 Feb 2018 19:06:08 High-throughput at Pfizer http://chem.vander-lingen.nl/articles/High-throughput at Pfizer/id/272/itemid/898 News from Pfizer Worldwide Research and Development! Perera et al. promise 1500 organic reactions per day at nanomole scale and write about it in Science (doi). The work is an extension of automation efforts by competitor Merck who managed 1500 plus reactions in 2.5 hours in 2014 (hello academia?) Thursday 01 Feb 2018 18:37:00 Introducing annulative chloroaryl dimerization http://chem.vander-lingen.nl/articles/Introducing annulative chloroaryl dimerization/id/271/itemid/897 In the journal Science this week Yoshito Koga et al. report on a new organic reaction type they call annulative dimerization (DOI). Imagine 2-chloro-p-terphenyl (carbon framework one up from biphenyl with a chlorine substituent in the middle section) get fused together at three edges. Apparently thi Wednesday 31 Jan 2018 20:38:25 Laboratory poison mystery http://chem.vander-lingen.nl/articles/Laboratory poison mystery/id/270/itemid/896 The people at Dart NeuroScience and Accela ChemBio have been treating us to a true laboratory poison mystery in the latest OPR and D (DOI). Who said that commercial organic chemistry could not be fun? Making money and do science! An otherwise unremarkable Suzuki reaction (coupling two aryls together Thursday 28 Dec 2017 18:26:59 Lanthanum decahydride http://chem.vander-lingen.nl/articles/Lanthanum decahydride/id/270/itemid/895 In last week's Angewandte Geballe et al. (Carnegie) report on a new strategy towards the elusive metallic hydrogen DOI. In a previous edition of this blog we were left with Dias and Silvera of Harvard trying to find out where their sample went, so a bit of good news is in order. Instead of filli Friday 22 Dec 2017 21:47:15 Algae microswimmers http://chem.vander-lingen.nl/articles/Algae microswimmers/id/269/itemid/894 In making-it-move news this week: weaponized spirulina platensis (make-it-move part XIX here) as reported by Li Zhang in Science Robotics (DOI) and the first microswimmer featured in this blog applied in an actual biological system! Spirulina is a microalgae with a natural helical shape and also wit Saturday 25 Nov 2017 12:39:44