NNNS chemistry blog http://chem.vander-lingen.nl Chemistry blog : news - comments - basics in chemistry en-us 1440 Target: chloroquine http://chem.vander-lingen.nl/articles/Target: chloroquine/id/297/itemid/957 The efficiency of chloroquine as an antiviral against COVID-19 is still in doubt with clinical trials running. For some time now I have had plans to piece together a summary of synthetic details. It does not help that I am locked out of the library but even with access, I doubt I am going to find th Saturday 04 Apr 2020 11:44:32 Target: hydroxychloroquine http://chem.vander-lingen.nl/articles/Target: hydroxychloroquine/id/296/itemid/956 Hydroxychloroquine is now prescribed in corona treatments in Europe even though the effectiveness of the drug as an antiviral is unsure (link). Antimalarial drug chloroquine was identified as a possible cure as early as the beginning of February but cousin hydroxychloroquine is considered less toxic Saturday 28 Mar 2020 12:20:34 Wanted: the Roche lysis buffer formula http://chem.vander-lingen.nl/articles/Wanted: the Roche lysis buffer formula/id/296/itemid/955 Pharmaceutical company Roche is taking some heat in The Netherlands after a publication by investigative platform "Follow The Money" (Link). Roche has a market share of 80% for the equipment currently used in corovirus testing (real-time PCR) and the hospitals and laboratories that use this equipmen Friday 27 Mar 2020 10:53:51 Target favipiravir http://chem.vander-lingen.nl/articles/Target favipiravir/id/296/itemid/954 New wonder drug Favipiravir is making the rounds in Corona land. (link) Produced by Japanese Toyama Chemical, the drug killed of the virus within 4 days in a Chinese human trial. The firm is a subsidiary of Fujifilm a rare example of obsolete photographic film maker reinventing itself as a hip antiv Friday 20 Mar 2020 22:11:32 Reactive nitrogen lockdown http://chem.vander-lingen.nl/articles/Reactive nitrogen lockdown/id/295/itemid/953 When farmers bring their own scientists to a negotiation. As already mentioned in an earlier blog The Netherlands is facing a reactive nitrogen crisis. It put the country in a active reactive nitrogen lock-down with building permits for large infrastructure projects revoked and something like a f Friday 21 Feb 2020 20:56:02 Remdesivir latest http://chem.vander-lingen.nl/articles/Remdesivir latest/id/295/itemid/952 With large parts of China in a lock down on account of the Wuhan corona virus the hunt is on for a defense, a treatment or a cure. A lot of attention is directed at vaccines as in regular flu but with development work, testing and production a working vaccine in the hands of medics can be months awa Sunday 02 Feb 2020 14:13:44 Hydrogen from seawater http://chem.vander-lingen.nl/articles/Hydrogen from seawater/id/295/itemid/951 Hydrogen is an efficient energy carrier. In many countries it can replace natural gas for heating and cooking in households with minor modifications to the existing infrastructure. It can also power cars and it can be used to store energy. The gas is relatively safe to use because its low density wi Wednesday 29 Jan 2020 21:12:28 Novel bismuth 3-5 catalytic cycle http://chem.vander-lingen.nl/articles/Novel bismuth 3-5 catalytic cycle/id/294/itemid/950 The research group of Josep Cornellà at the Max-Planck-Institut für Kohlenforschung has reported on a new use of bismuth in catalysis (Planas, Wang DOI). Cornellà has a longstanding interest in coupling reactions and it will come as no surprise the particular field of catalysis concerns fluorination Monday 20 Jan 2020 21:26:37 New in Grignards http://chem.vander-lingen.nl/articles/New in Grignards/id/294/itemid/949 Researchers from the Fraunhofer IMM institute in Germany have devised a metal reactor for the continuous delivery of Grignard reagents as reported in OPR and D (DOI). The lab-scale synthesis of these reagents is always a challenge let alone their use in industry. The authors note the dependence on t Sunday 19 Jan 2020 20:47:22 Industrial scale calixarenes http://chem.vander-lingen.nl/articles/Industrial scale calixarenes/id/294/itemid/948 It is one of these classic Organic Syntheses preps: para-t-butyl-8-calixarene (DOI). Just take para-tert-butylphenol, paraformaldehyde, sodium hydroxide and xylene, stir and reflux and out comes the wonderfully vase shaped molecule. In a recent JOC contribution Cornelius Haase has been re-investiga Sunday 05 Jan 2020 13:05:19 2D ice growth revealed http://chem.vander-lingen.nl/articles/2D ice growth revealed/id/294/itemid/947 Ever wondered how a two-dimensional nanosheet of ice grows on the edges? With a good sense of public relations (submitted to Nature in May but published online January 1 2020, first research article in a new decade) Runze Ma et al. (DOI) have tried to find out. They grew a 2D hexagonal bilayer of ic Saturday 04 Jan 2020 20:41:06 Novel disulfide reducing agent http://chem.vander-lingen.nl/articles/Novel disulfide reducing agent/id/293/itemid/946 Mthembu et al. report on a new reducing agent for disulfides (DOI). A range of such agents widely used in biochemistry are 2-mercaptoethanol, dithiothreitol (DTT) and TCEP and serve deprotection purpose and can cleave spacers. They all tend to suffer from poor reducing power, low reactivity, limited Saturday 07 Dec 2019 12:02:55 A MOF for nitrogen dioxide http://chem.vander-lingen.nl/articles/A MOF for nitrogen dioxide/id/293/itemid/945 Schröder and Yang of the University of Manchester report on a new way to remove nitrogen dioxide from an exhaust using MOF's (Li et al. DOI). NOx compounds are hazardous to human health and damage eco systems. The diesel emissions scandal made clear new ways to tackle NOx are in need (previous repor Tuesday 03 Dec 2019 21:25:40 The hamburger problem http://chem.vander-lingen.nl/articles/The hamburger problem/id/292/itemid/944 In a recent article submitted to chemrxiv Christopher Southan introduces the reader to the hamburger problem in big data science (link). There are two things that are keeping data scientists from mining the huge mountain of scientific data that has accumulated over the past 200 years. One of them is Saturday 23 Nov 2019 10:03:03 PFAS lock down http://chem.vander-lingen.nl/articles/PFAS lock down/id/291/itemid/943 The Netherlands are already in a reactive nitrogen lock down with 18,000 building and construction projects halted indefinitely because reactive nitrogen emissions from these projects destroy biodiversity. One possible solution considered by policy makers is the reduction of the agro industry (takin Saturday 26 Oct 2019 13:47:46 A hexagonal planar complex http://chem.vander-lingen.nl/articles/A hexagonal planar complex/id/291/itemid/942 A hexagonal planar transition metal complex is reported from the Crimmin Group (Marti Garçon et al. DOI). In textbook chemistry any metal with 6 ligands either adopts a Trigonal prismatic molecular geometry or a Octahedral molecular geometry geometry so this arrangement is unusual. The new compound Monday 21 Oct 2019 21:14:31 New in SLA http://chem.vander-lingen.nl/articles/New in SLA/id/291/itemid/941 Unusual to see the three authors of a Science article also listed as the CEO, CTO and chairman of a commercial business. The article is about 3D printing (DOI) and the company is 3D printing company Azul3D. Okay, Walker, Hedrick and Mirkin also work at Northwestern University. Stereolithography Wednesday 09 Oct 2019 18:42:51 New in CASP http://chem.vander-lingen.nl/articles/New in CASP/id/290/itemid/940 Quick update from the field of CASP (Computer Assisted Synthesis Planning) by Thakkar / Kogey / Reymond / Engkvist / Bjerrum in a recent ChemRxiv article (DOI). In it they bring artificial intelligence to retrosynthetic analysis, a particular chemical human art thus far obtained "through years of ex Sunday 29 Sep 2019 14:42:59 New in nitrogen reduction http://chem.vander-lingen.nl/articles/New in nitrogen reduction/id/290/itemid/939 New nitrogen reduction paper out on ChemRxiv (Bruch et al. DOI). See earlier nitrogen reduction coverage here and here. Alexander Miller heads the Miller group at UNC and has been publishing about catalysis since 2005. The publication trail almost inevitably has been leading up to nitrogen reduction Monday 16 Sep 2019 18:48:06 Tetravinylallene http://chem.vander-lingen.nl/articles/Tetravinylallene/id/290/itemid/938 Tetravinylallene is new improbable molecule out of the laboratory of M.S. Sherburn (Elgindy et al. DOI). This blog has been reporting about earlier stranger things such as divinylallene in 2011 and 3-vinyl-1,4,heptadiene in 2012. They all belong to a class of hydrocarbons called dendralenes that hav Friday 13 Sep 2019 13:23:41