NNNS chemistry blog http://chem.vander-lingen.nl Chemistry blog : news - comments - basics in chemistry en-us 1440 A solvent for tellurium http://chem.vander-lingen.nl/articles/A solvent for tellurium/id/225/itemid/764 Webber et al. report a new method for the synthesis of tin telluride, a compound of some relevance as semiconductor (DOI). The avenue towards the new method was opened by the development of a new solvent system for elemental tellurium. The researchers note that tellurium has a poor solubility record Friday 18 Apr 2014 20:57:44 The on-solvent reaction http://chem.vander-lingen.nl/articles/The on-solvent reaction/id/225/itemid/763 Never expected to one day see mercury listed as an organic solvent but it has happened. Here is how. Sela and Vigalok have been investigating the on water reaction and are reporting about it here. In this type of reaction, water is added to an ordinary organic reaction forming an emulsion and ther Friday 04 Apr 2014 21:20:13 This molecule must be in so much pain http://chem.vander-lingen.nl/articles/This molecule must be in so much pain/id/225/itemid/762 This molecule must be in so much sprain. In alkynes the bond angles are usually 180° but here the diacetylene unit makes an angle of 160°. It was synthesised in a simple intramolecular acetylene coupling with copper acetate in a 52% yield. Degradation starts at 70°, triggered by benzyne formation in Wednesday 02 Apr 2014 21:59:51 The thermoresponsive microjet http://chem.vander-lingen.nl/articles/The thermoresponsive microjet/id/224/itemid/761 In our ongoing making-it-move coverage (previous episode here) now the thermoresponsive microjet as reported by Magdanz here. We have seen hydrogen peroxide / metal / vesicle based micro-swimmers before but the dimension added is on-demand weaponisation. Key is the vesicle construction material. It Thursday 27 Mar 2014 21:21:58 Industrial artemisinin http://chem.vander-lingen.nl/articles/Industrial artemisinin/id/224/itemid/760 As reported back in 2012 here chemical company Sanofi and the Bill and Melinda Gates Foundation have joined forces (Sanofi the know-how and Bill the money) to increase production of the important antimalarial drug artemisinin. In a recent OPRD publication Sanofi chemists present a commercial-scale ( Sunday 16 Mar 2014 16:43:01 A molecule cannot be rare http://chem.vander-lingen.nl/articles/A molecule cannot be rare/id/224/itemid/759 Thanks to tetrahedral carbon the number of possible molecules that can exist seems infinite. Any child can take a piece of paper and draw a completely unique molecule on it and name it after itself, sticking to the basic rules of valence, multiple bonding and some common sense with regard to clutter Saturday 15 Mar 2014 19:47:29 That is uranium from seawater. http://chem.vander-lingen.nl/articles/That is uranium from seawater./id/224/itemid/758 The sea is worth money. It contains 3.2 mg per tonne of uranium in the form of uranyl and no one owns it yet. But how to extract it? The competition is stiff. Seawater is (still) basic and abundant carbonate ions chelate well to uranium. Calcium ions are also abundant and compete with uranyl based o Tuesday 11 Mar 2014 21:57:59 Novel diradical http://chem.vander-lingen.nl/articles/Novel diradical/id/223/itemid/757 Yuan Lu et al. describe here a novel diradical compound. Synthetic details: 2-mesitylmagnesium bromide Grignard reaction to dialdehyde 1, Friedel-Crafts reaction with boron trifluoride on diol 2 to hydrocarbon 3 and then deprotonation with lithium diisopropylamide to the dianion (green THF solution Saturday 15 Feb 2014 18:29:21 Superbase superacid http://chem.vander-lingen.nl/articles/Superbase superacid/id/223/itemid/756 Two chemistry world records in rapid succession. Record one: a superbase as reported by Vadzar here. Superbases are nothing new, examples are TMG with an pK<sub>a</sub> of the conjugated acid of 17, phosphazene base tBu<sub>P1</sub>(pyrr) (20,2), triazabicyclodecene (21.7) and a guanidino-phosphazen Friday 07 Feb 2014 23:43:03 Nanoribbons, the bottom-way up http://chem.vander-lingen.nl/articles/Nanoribbons, the bottom-way up/id/223/itemid/755 A previous episode of this blog reported on the synthesis of nanotubes starting from 12-cycloparaphenylene. In a very new bottom-up approach described here the starting material for a closely related nanoribbon is a slightly modified tetraphenylcyclopentadienone. Added functional group is an alkyne Sunday 02 Feb 2014 21:36:33 Oxyluciferin revisited http://chem.vander-lingen.nl/articles/Oxyluciferin revisited/id/222/itemid/754 The firefly problem has already been solved in 2009 here but why is oxylucerifin so unstable? Supposedly it is impossible to have it synthesised. Maltsev et al. have been doing some reinvestigation on the synthesis of the compound from 2-cyano-6-hydroxybenzothiazole and ethyl 2-mercaptoacetate in a Friday 31 Jan 2014 19:21:43 Phosphorene http://chem.vander-lingen.nl/articles/Phosphorene/id/222/itemid/753 New in the exclusive family of single-layered two-dimensional materials that includes graphene molybdenum disulfide and silicene: phosphorene! as reported by Han Liu et al. here (not peer-reviewed so absorb with caution). Not exactly monolayer, the researchers call their invention 'few-layer phosph Friday 24 Jan 2014 18:46:02 The organic-inorganic flow battery http://chem.vander-lingen.nl/articles/The organic-inorganic flow battery/id/222/itemid/752 Flow batteries are nothing new and metal-free inorganic flow batteries are nothing new either (see for example the polysulfide bromide battery) but the set is not complete with an metal-free organic variation as well. The new flow battery described here works with two flows that meet separated by ca Friday 17 Jan 2014 20:58:48 Himmel, Krossing and Schnepf on dative bonds http://chem.vander-lingen.nl/articles/Himmel, Krossing and Schnepf on dative bonds/id/222/itemid/751 A dative bond takes place between an atom with an available lone pair and an atom that is an electron acceptor. A good example is the adduct of ammonia and borane or ammonia borane with the dative bond depicted as H<sub>3</sub>N->BH<sub>3</sub> with an arrow indicating that nitrogen is donating bot Saturday 11 Jan 2014 22:08:36 Introducing the aromatic ene reaction http://chem.vander-lingen.nl/articles/Introducing the aromatic ene reaction/id/219/itemid/750 From the same people who brought you the hexadehydro-Diels-Alder reaction (HDDA), there is now the aromatic ene reaction (Niu and Hoye DOI). The HDDA reaction is a cyclotrimerization of a linear triyne to an aryne. This thermal reaction does not require any reagents and does not leave side-produc Tuesday 24 Dec 2013 21:58:08 Table salt not as you know it http://chem.vander-lingen.nl/articles/Table salt not as you know it/id/219/itemid/749 Bored with NaCl? Try NaCl2! or NaCl3, 4, 7?. Reduce your sodium in an unexpected way. Instructions here. NaCl7 is stable at pressures in excess of 142 GPa but the definition of stable here is a broad one: anything more stable than any competitor at the given physical space. The crystal structure is Tuesday 24 Dec 2013 18:54:45 Surechem review http://chem.vander-lingen.nl/articles/Surechem review/id/219/itemid/748 With thanks to In The Pipeline for the alert, a new open-source chemical database has launched called SureChEMBL / Surechem. The venture boasts a collection of 9 million chemical structures from patents, half of which are not contained in another database. Registration is easy: as often, even th Saturday 14 Dec 2013 18:09:38 Giants in chemistry are not what you think they are http://chem.vander-lingen.nl/articles/Giants in chemistry are not what you think they are/id/219/itemid/747 A recent xkcd comic demonstrating various degrees of large in astronomical telescopes reminded this blog of the preoccupation of some chemists with giants. Giants appear to pop up in the strangest of places. Take for example a giant spokewheel here. Considering that this conjugated macrocycle is onl Friday 06 Dec 2013 21:34:52 Oxidation by oxygen http://chem.vander-lingen.nl/articles/Oxidation by oxygen/id/218/itemid/746 Oxidation by oxygen. Whenever you are in need of oxidizing a compound, oxygen must be the obvious choice. It is not, explosion risk plays a role. Not for the first time now a France-based research group takes up the challenge. They demonstrate here how it could be done with substrate 2-ethylhexanal Saturday 30 Nov 2013 17:55:55 Improved Suzuki−Miyaura Cross-Coupling http://chem.vander-lingen.nl/articles/Improved Suzuki−Miyaura Cross-Coupling/id/218/itemid/745 Reaction type: Suzuki-Miyaura coupling Source: DOI Novelty: use of MIDA boronate, no organic solvent, just water. Tocopherol based surfactant creates a "nanoreactor" E-factor: close to zero Bottlenecks: Et3N only base that works. Upsides: aqueous filtrates can be recycled. Friday 15 Nov 2013 18:24:33