NNNS chemistry blog http://chem.vander-lingen.nl Chemistry blog : news - comments - basics in chemistry en-us 1440 A case of failed Suzuki http://chem.vander-lingen.nl/articles/A case of failed Suzuki/id/301/itemid/965 Wethman et al. warn of the use of sodium methoxide in Suzuki reactions in an article published on Chemrxiv (DOI). The research is a collaboration between Bristol Myers Squibb (must be the people with the failing Suzuki) and Scripps Research (the people with the fancy analytical equipment). Case at h Sunday 09 Aug 2020 12:24:48 CRD update http://chem.vander-lingen.nl/articles/CRD update/id/301/itemid/964 Update on the Chemical Reaction Database (CRD) project that was started back in 2012 (link, link, link). The idea is simple, construct a public website containing a database of chemical reactions as an alternative to the existing pay-walled ones. Data of chemical reactions is taken from the general Sunday 09 Aug 2020 12:24:48 Vancomycin latest http://chem.vander-lingen.nl/articles/Vancomycin latest/id/302/itemid/966 A new vancomycin total synthesis has been reported by Moore et al. in a recent article in JACS (DOI). Vancomycin is a critical antibiotic in the war on bugs. In his book on the human body, author Bill Bryson explains how this war is progressing: the humans are loosing. The use of antibiotics is wide Sunday 09 Aug 2020 12:24:48 Hexacyclohexylcyclohexane http://chem.vander-lingen.nl/articles/Hexacyclohexylcyclohexane/id/300/itemid/963 Dillenburger et al. report the chemical anaysis of hexacyclohexylcyclohexane which is cyclohexane with on every carbon atom a cyclohexyl unit (DOI). To arrive at this result hexaphenylbenzene was hydrogenated in an autoclave with hydrogen and palladium on carbon at 250 bar and 150 degrees for four Monday 27 Jul 2020 21:07:41 A case of contaminated paracetamol http://chem.vander-lingen.nl/articles/A case of contaminated paracetamol/id/300/itemid/962 News item in the Netherlands: newspaper NRC and investigative TV program Zembla have uncovered contaminated paracetamol for sale to consumers (NRC piece). The contaminant is 4-chloroaniline, a compound that is listed at the European Food Safety Authority (EFSA) as a genotoxic carcinogen. The levels Friday 10 Jul 2020 14:20:18 The robotic chemist http://chem.vander-lingen.nl/articles/The robotic chemist/id/300/itemid/961 The University of Liverpool has introduced a mobile robotic chemist. The features of this oversized suitcase on wheels with an industrial robot arm on top are described by Burger et al. in the journal Nature (DOI). They are impressive. It navigates through a regular laboratory with a combination of Thursday 09 Jul 2020 20:31:24 Tencent goes retro http://chem.vander-lingen.nl/articles/Tencent goes retro/id/299/itemid/960 A new entry in the field of retrosynthesis prediction: Chinese conglomerate (60k employees) Tencent has put a paper out on ChemRxiv through its Tencent AI Lab in Washington (Chaochao Yan et al. DOI). Traditionally retrosynthesis is the domain of very experienced organic chemists who deconstruct a ta Friday 12 Jun 2020 22:02:49 Halogen sodium zinc carbon dance http://chem.vander-lingen.nl/articles/Halogen sodium zinc carbon dance/id/298/itemid/959 Interesting halogen sodium zinc carbon dance reported by Sobi Asako et al (DOI) and a new chapter in a long standing lithium sodium feud. Basic idea, sodium could replace lithium in just about any organolithium application because sodium is cheaper and organosodium unlike lithium has been around sin Sunday 31 May 2020 16:49:46 Chemical Zoo: C2 http://chem.vander-lingen.nl/articles/Chemical Zoo: C2/id/298/itemid/958 The synthesis of C<sub>2</sub> has been reported by Miyamoto et al. (DOI) This long elusive chemical compound (impossible to make!) has a long history and even an history in this blog. In 2012 it was mentioned in connection to computations reported by Sason Shaik et al. (link) and in 2013 the blog Sunday 03 May 2020 21:16:20 Target: chloroquine http://chem.vander-lingen.nl/articles/Target: chloroquine/id/297/itemid/957 The efficiency of chloroquine as an antiviral against COVID-19 is still in doubt with clinical trials running. For some time now I have had plans to piece together a summary of synthetic details. It does not help that I am locked out of the library but even with access, I doubt I am going to find th Saturday 04 Apr 2020 11:44:32 Target: hydroxychloroquine http://chem.vander-lingen.nl/articles/Target: hydroxychloroquine/id/296/itemid/956 Hydroxychloroquine is now prescribed in corona treatments in Europe even though the effectiveness of the drug as an antiviral is unsure (link). Antimalarial drug chloroquine was identified as a possible cure as early as the beginning of February but cousin hydroxychloroquine is considered less toxic Saturday 28 Mar 2020 12:20:34 Wanted: the Roche lysis buffer formula http://chem.vander-lingen.nl/articles/Wanted: the Roche lysis buffer formula/id/296/itemid/955 Pharmaceutical company Roche is taking some heat in The Netherlands after a publication by investigative platform "Follow The Money" (Link). Roche has a market share of 80% for the equipment currently used in corovirus testing (real-time PCR) and the hospitals and laboratories that use this equipmen Friday 27 Mar 2020 10:53:51 Target favipiravir http://chem.vander-lingen.nl/articles/Target favipiravir/id/296/itemid/954 New wonder drug Favipiravir is making the rounds in Corona land. (link) Produced by Japanese Toyama Chemical, the drug killed of the virus within 4 days in a Chinese human trial. The firm is a subsidiary of Fujifilm a rare example of obsolete photographic film maker reinventing itself as a hip antiv Friday 20 Mar 2020 22:11:32 Reactive nitrogen lockdown http://chem.vander-lingen.nl/articles/Reactive nitrogen lockdown/id/295/itemid/953 When farmers bring their own scientists to a negotiation. As already mentioned in an earlier blog The Netherlands is facing a reactive nitrogen crisis. It put the country in a active reactive nitrogen lock-down with building permits for large infrastructure projects revoked and something like a f Friday 21 Feb 2020 20:56:02 Remdesivir latest http://chem.vander-lingen.nl/articles/Remdesivir latest/id/295/itemid/952 With large parts of China in a lock down on account of the Wuhan corona virus the hunt is on for a defense, a treatment or a cure. A lot of attention is directed at vaccines as in regular flu but with development work, testing and production a working vaccine in the hands of medics can be months awa Sunday 02 Feb 2020 14:13:44 Hydrogen from seawater http://chem.vander-lingen.nl/articles/Hydrogen from seawater/id/295/itemid/951 Hydrogen is an efficient energy carrier. In many countries it can replace natural gas for heating and cooking in households with minor modifications to the existing infrastructure. It can also power cars and it can be used to store energy. The gas is relatively safe to use because its low density wi Wednesday 29 Jan 2020 21:12:28 Novel bismuth 3-5 catalytic cycle http://chem.vander-lingen.nl/articles/Novel bismuth 3-5 catalytic cycle/id/294/itemid/950 The research group of Josep Cornellà at the Max-Planck-Institut für Kohlenforschung has reported on a new use of bismuth in catalysis (Planas, Wang DOI). Cornellà has a longstanding interest in coupling reactions and it will come as no surprise the particular field of catalysis concerns fluorination Monday 20 Jan 2020 21:26:37 New in Grignards http://chem.vander-lingen.nl/articles/New in Grignards/id/294/itemid/949 Researchers from the Fraunhofer IMM institute in Germany have devised a metal reactor for the continuous delivery of Grignard reagents as reported in OPR and D (DOI). The lab-scale synthesis of these reagents is always a challenge let alone their use in industry. The authors note the dependence on t Sunday 19 Jan 2020 20:47:22 Industrial scale calixarenes http://chem.vander-lingen.nl/articles/Industrial scale calixarenes/id/294/itemid/948 It is one of these classic Organic Syntheses preps: para-t-butyl-8-calixarene (DOI). Just take para-tert-butylphenol, paraformaldehyde, sodium hydroxide and xylene, stir and reflux and out comes the wonderfully vase shaped molecule. In a recent JOC contribution Cornelius Haase has been re-investiga Sunday 05 Jan 2020 13:05:19 2D ice growth revealed http://chem.vander-lingen.nl/articles/2D ice growth revealed/id/294/itemid/947 Ever wondered how a two-dimensional nanosheet of ice grows on the edges? With a good sense of public relations (submitted to Nature in May but published online January 1 2020, first research article in a new decade) Runze Ma et al. (DOI) have tried to find out. They grew a 2D hexagonal bilayer of ic Saturday 04 Jan 2020 20:41:06