NNNS chemistry blog http://chem.vander-lingen.nl Chemistry blog : news - comments - basics in chemistry en-us 1440 Curiosity does it again http://chem.vander-lingen.nl/articles/Curiosity does it again/id/276/itemid/906 I have the Curiosity rover in my Twitter contacts and last Thursday it had some great news to share, organic material found at last! The research done it had its colleagues on Earth write it all up in an article in Science. (DOI). Here are the key findings. The soil drill site was on a mudstone sur Friday 08 Jun 2018 21:48:48 DIY Vorinostat http://chem.vander-lingen.nl/articles/DIY Vorinostat/id/275/itemid/905 It does not stop: after Orkambi (link) and chenodeoxycholic acid (link) we now have another enterprising Dutch dispensing pharmacist home-brewing a an otherwise really expensive drug (NOS news). This time the drug is Vorinostat now available for patients at the AVL hospital not for the retail price Thursday 10 May 2018 21:14:45 Whitesides on total synthesis http://chem.vander-lingen.nl/articles/Whitesides on total synthesis/id/274/itemid/904 George Whitesides has recently shared his thoughts on organic synthesis in an essay in The Israel Journal of Chemistry (DOI) In it he asks the big question about its future. Being a functional materials man Whitesides of course contrasts the aesthetics of complex biomolecule synthesis with the pract Saturday 14 Apr 2018 10:37:32 Baran on Total Synthesis http://chem.vander-lingen.nl/articles/Baran on Total Synthesis/id/274/itemid/903 Almost written as a counter-essay to the Whitesides article on Organic Synthesis, Phil Baran has expressed his take on total synthesis in a recent JACS editorial. (DOI). The title suggests it is just another propaganda piece: "As Exciting as Ever and Here To Stay" but you cannot blame him. According Saturday 07 Apr 2018 17:55:03 DIY chenodeoxycholic acid http://chem.vander-lingen.nl/articles/DIY chenodeoxycholic acid/id/274/itemid/902 In a previous episode this blog has been reporting on a Dutch dispensing chemist who took it on himself the affordable production of a certain drug, otherwise only available from the pharmaceutical industry at highly inflated prices. This week in the news (link) a hospital doing something similar. Friday 06 Apr 2018 18:23:47 New in phosphorus chemistry http://chem.vander-lingen.nl/articles/New in phosphorus chemistry/id/273/itemid/901 How to recap this article: how to get from phosphate rock to drug fosinopril, but in two different ways? Seems a bit odd, just like discussing the merits of oil production from in the context of aspirin synthesis. <br /><br /> Geeson and Cummins do just that in a recent Science article (DOI). They Friday 30 Mar 2018 20:42:49 The physics of ice scating http://chem.vander-lingen.nl/articles/The physics of ice scating/id/272/itemid/900 With the start of the 2018 Winter Olympics it seemed my local newspaper The Volkskrant a great idea to include a segment on one of the great unsolved problems in physics: ice scating. If you look at the current unsolved problems Wikipedia page the official list contains the heavy-weight issues from Saturday 10 Feb 2018 22:03:37 Energy crisis in The Netherlands http://chem.vander-lingen.nl/articles/Energy crisis in The Netherlands/id/272/itemid/899 The Gasmolecule is a sculpture of a methane molecule with a height of 8 meters and is located in Slochteren in the province of Groningen in the North of the Netherlands. The sculpture commemorates the find of a massive natural gas field (2700 billion cubic meters) in 1959 that has since provided mil Friday 02 Feb 2018 19:06:08 High-throughput at Pfizer http://chem.vander-lingen.nl/articles/High-throughput at Pfizer/id/272/itemid/898 News from Pfizer Worldwide Research and Development! Perera et al. promise 1500 organic reactions per day at nanomole scale and write about it in Science (doi). The work is an extension of automation efforts by competitor Merck who managed 1500 plus reactions in 2.5 hours in 2014 (hello academia?) Thursday 01 Feb 2018 18:37:00 Introducing annulative chloroaryl dimerization http://chem.vander-lingen.nl/articles/Introducing annulative chloroaryl dimerization/id/271/itemid/897 In the journal Science this week Yoshito Koga et al. report on a new organic reaction type they call annulative dimerization (DOI). Imagine 2-chloro-p-terphenyl (carbon framework one up from biphenyl with a chlorine substituent in the middle section) get fused together at three edges. Apparently thi Wednesday 31 Jan 2018 20:38:25 Laboratory poison mystery http://chem.vander-lingen.nl/articles/Laboratory poison mystery/id/270/itemid/896 The people at Dart NeuroScience and Accela ChemBio have been treating us to a true laboratory poison mystery in the latest OPR and D (DOI). Who said that commercial organic chemistry could not be fun? Making money and do science! An otherwise unremarkable Suzuki reaction (coupling two aryls together Thursday 28 Dec 2017 18:26:59 Lanthanum decahydride http://chem.vander-lingen.nl/articles/Lanthanum decahydride/id/270/itemid/895 In last week's Angewandte Geballe et al. (Carnegie) report on a new strategy towards the elusive metallic hydrogen DOI. In a previous edition of this blog we were left with Dias and Silvera of Harvard trying to find out where their sample went, so a bit of good news is in order. Instead of filli Friday 22 Dec 2017 21:47:15 Algae microswimmers http://chem.vander-lingen.nl/articles/Algae microswimmers/id/269/itemid/894 In making-it-move news this week: weaponized spirulina platensis (make-it-move part XIX here) as reported by Li Zhang in Science Robotics (DOI) and the first microswimmer featured in this blog applied in an actual biological system! Spirulina is a microalgae with a natural helical shape and also wit Saturday 25 Nov 2017 12:39:44 Do it yourself pharma http://chem.vander-lingen.nl/articles/Do it yourself pharma/id/269/itemid/893 Big news in The Netherlands: a dispensing chemist in The Hague is challenging a pharmaceutical company by starting a pharmaceutical production line in the back of his shop rather than being forced to wholesale some really expensive medicine (NOS News). The pharma bro's are Vertex, the product is Or Tuesday 21 Nov 2017 20:52:46 Spectacular magnet failure http://chem.vander-lingen.nl/articles/Spectacular magnet failure/id/269/itemid/892 The other day I bought a set of magnets that failed the moment I unpacked them. At 4 euro's not the end of the world but the material failure was spectacular. The button-sized pieces of metal just shattered on any impact, made worse by their large magnetic strength. So before returning them to the Sunday 12 Nov 2017 20:35:29 Duped! http://chem.vander-lingen.nl/articles/Duped!/id/268/itemid/891 From September 2014 to June 2017 Wikipedia user Carolineneil was creating one new chemistry page after the other. Typical titles were 'Modified Wittig-Claisen tandem reaction' and 'Multivalued treatment'. These articles had serious issues and fellow editors and administrators spent many hours sortin Friday 06 Oct 2017 18:46:38 You can call me Al=Al http://chem.vander-lingen.nl/articles/You can call me Al=Al/id/267/itemid/890 A seemingly odd article from the Catalysis Research Center and Institute of Silicon Chemistry, the presentation of an aluminum to aluminum double bond compound (Bag et al. DOI) but silicon has everything to do with it. This dialumene (Al=Al) in question is stabilised by two NHC carbene ligands bot Wednesday 13 Sep 2017 19:54:50 Desalination with a battery http://chem.vander-lingen.nl/articles/Desalination with a battery/id/266/itemid/889 A battery can be used as a desalination plant. The technique is called capacitive deionization: apply a current over two electrodes and use them to temporarily to store the sodium ions and chloride ions and create deionised water. At discharge release the ions again to produce concentrated salt wast Friday 04 Aug 2017 22:12:58 Niemeier and Tilmes on global cooling http://chem.vander-lingen.nl/articles/Niemeier and Tilmes on global cooling/id/265/itemid/888 In a recent Science perspective Niemeier (Max Planck Institute for Meteorology) and Tilmes ( National Center for Atmospheric Research) nicely sum up the present state of climate engineering with sulfur (DOI). In a nutshell: somehow inject a lot of sulfur into the atmosphere and make it counter globa Sunday 23 Jul 2017 22:21:11 Herbicides and where to find them http://chem.vander-lingen.nl/articles/Herbicides and where to find them/id/265/itemid/887 An interesting notion from Corral et al. in the Angewandte: when scouting for new herbicides look at existing antimalarial drugs (DOI). The rationale: malaria and plants share part of their evolution. Where the malaria parasite Plasmodium falciparum has an apicoplast (a kind of organelle used for st Saturday 22 Jul 2017 13:08:04