The Bargellini reaction

02 May 2009 - Named reactions

Name: Bargellini reaction - Bargellini, G. Gazz. Chim. Ital. 1906, 36, 329
What: multicomponent reaction of a phenol, a ketone, chloroform and potassium hydroxide forming a sterically hindered alpha-phenoxy-isobutyric acid:


Recent sightings: the reagent chloretone is the ketone and chloroform rolled in one for example (Cvetovich et al. DOI):

The reaction is also found to work with aniline derivatives (Butcher et al. DOI):