A large Germany-based team (Stefan Grimme of FLP fame among them) report a record 12-step cascade reaction (Dückert et al. 2011 DOI) in their quest for novel (medicinal?) indoloquinolizines. They like to call their effort biology-oriented synthesis because nature just loves cascade reactions in the construction of really large and complex molecules. The reaction takes place in a single vessel and starts off with three reagents. At a later stage a fourth and fifth are added which, considering the definition of a cascade reaction (all-in-one intramolecular reaction) technically makes it a combined 4 and 8-step cascade.