What : difluoromethylation
Reagent: difluoromethyltriflate, air stable liquid
Source: DOI (Fier & Hartwig)
Rationale: current methods require ozone depleting Freon 22 (gas) Relevant to pharma (example Pantoprazole)
Substrates: Phenols, aryl boronic acids
Mechanism: proceeds via difluorocarbene. Isotope labeling evidence