Improved Suzuki−Miyaura Cross-Coupling

15 November 2013 - CRD 153

5-(p-tolyl)pyrimidine.PNG Reaction type: Suzuki-Miyaura coupling
Source: DOI
Novelty: use of MIDA boronate, no organic solvent, just water. Tocopherol based surfactant creates a "nanoreactor"
E-factor: close to zero
Bottlenecks: Et3N only base that works.
Upsides: aqueous filtrates can be recycled.