Asymmetric Strecker

21 October 2009 - Check this out

asymmetric Strecker Zuend 2009
Check: reaction type Strecker reaction
Check: keywords organocatalysis asymmetric synthesis
Check: Published in Nature Zuend et al. 2009 DOI Jacobsen lab.
Check: substrate imine
Check: reagents trimethylsilyl cyanide, methanol, a thiourea catalyst. See organocatalysis
Check: utility. The reaction product a chiral tert-butyl leucine can be used as a starting material for synthesis of HIV protease inhibitor atazanavir.
Check: More Strecker here