|Just as easy as total synthesis was laid to rest in the last episode of this blog - sorry pointless, time to move on - The Baran lab this week makes a clear case to continue business as usual: total synthesis is important! Case at hand: what the hell is in Taiwanofungus camphoratus that makes it the fantastic medicinal mushroom that it is. Golden Biotech Corp has been certain the active ingredient is antroquinonol A and is currently running clinical trials. But is it? The Baran lab produced pure gram-scale (+)-antroquinonol A via classic total synthesis (Villaume et al. doi) and did some clinical laboratory trials of it's own. Main conclusion: antroquinonol A nor one of its main metabolites did show any antitumor activity. |
In chemistry land these must be exiting times. If antroquinonol is not the active ingredient then what is? Dozens of chemistry labs must by now have joined a new race. Cancel all Christmas holidays!
With thanks to Fluorogrol for the alert (@Twitter)